An acute study with benzoic acid by gavage in male and female mice was available to the European Food Safety Authority Panel. (Fifty-seventh report of the Joint FAO/WHO Expert Committee on Food Additives). The addition of benzoic acid to yogurt is not allowed, and the amount of benzoic acid in yogurt should not exceed 50 mg/kg 19). To assess the dietary exposure to benzoic acid-benzoates (E 210–213) from their use as a food additive, the exposure was calculated based on (1) maximum permitted levels set out in the EU legislation (defined as the regulatory maximum level exposure assessment scenario) and (2) the reported use levels and analytical data (defined as the refined exposure assessment scenario). Benzoic acid and a wide range of derivatives and related benzenic compounds, such as salts, alkyl esters, parabens, benzyl Ortho-benzoylbenzoic Acid 14. The European Food Safety Authority Panel on Food Additives, Flavorings, Processing Aids and Food Contact Materials concluded that the study provides limited evidence that the two different mixtures of synthetic colours and sodium benzoate tested had a small and statistically significant effect on activity and attention in some children selected from the general population, although the effects were not observed for all children in all age groups and were not consistent for the two mixtures. McNeal TP, Nyman PJ, Diachenko GW and Hollifield HC, 1993. Benzoic acid is generally effective in controlling mold and inhibiting yeast growth and also in preventing a wide range of bacterial attacks 17). Information regarding skin reactions caused by benzoic acid in the general population is limited 12). An optical test strip for the detection of benzoic acid in food. Fourth Edition. Consequently, the absorption, distribution, metabolism and excretion of this salt will be similar to that of the sodium or potassium salts, despite differences in water solubility. US Patent 3867439 A. EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources), 2011. Benzoic acid. Other uses for benzoic acid and its salts include regulated use as food preservatives, most Summary record of the Standing Committee on the Food Chain and Animal Health. The results of the available short-term and subchronic studies on benzoic acid and its salts indicated that their toxicity is low, with no marked target organ toxicity, although high intakes of benzoic acid may lead to disturbances in the acid/base balance, and benzoic acid at high doses may interfere with intermediary metabolism. Dietary exposure through this latter scenario was assessed using two sets of concentration data: reported use levels and analytical data not exceeding the maximum permitted levels for food categories for which direct addition of benzoic acid-benzoates is authorized; and reported use levels and analytical data not exceeding the maximum permitted levels for food categories for which direct addition of benzoic acid-benzoates is authorized and analytical data for food categories which may contain benzoic acid benzoates due to carry-over and for which data were available. Reports of the Scientific Committee for Food, Thirty-Fifth Series. 23) study that has concluded that exposure to two mixtures of four synthetic colors plus sodium benzoate, as a preservative, in the  diet resulted in increased hyperactivity in 3-year-old and 8- to 9-year-old children in the general population. Detailed information related to Benzoic Acid's uses, side-effects, reviews, questions, interactions, and precautions is as follows: Along with other acne-fighting additives, some products contain sulphur, such as resorcinol. It is excreted as hippuric acid after conjugation with glycine in the liver. Benzoic acid and its salts are primarily used as food preservatives in acidified foodstuffs and beverages such as fruit juice, soft drinks and carbonated drinks. In its opinion on the re-evaluation of calcium carbonate (E 170) as a food additive 16), the European Food Safety Authority Panel noted that limestone may contain aluminium at concentrations up to 190 mg/kg. Moreover, the European Food Safety Authority Panel noted that the available data did not indicate any carcinogenic potential 9). Other esters, including benzyl formate and benzyl acetate, are also present. Evaluation of certain food additives and contaminants. In a developmental toxicity study in rats with benzoic acid by gavage, a no observed adverse effect level (NOAEL) of 160 mg benzoic acid/kg body per day was observed for maternal and developmental toxicity The developmental toxicity studies in rats with sodium benzoate in the diet showed a no observed adverse effect level (NOAEL) of 500 mg/kg body weight per day comparable to the NOAEL of the dietary four-generation reproductive toxicity in rats with benzoic acid. Contain as much as 300-1300 mg free benzoic acid preservative prevents or delays losses... Bfr ( Bundesinstitut für Risikobewertung [ Federal benzoic acid uses for Occupational Safety and )... Of oxygen in this medication guide Safety ], 5, 443–452 present at low concentrations in water. Subchronic studies on benzoic acid in the general population is limited 12.. When sugar is replaced with intense sweeteners in soft drinks, and unreacted toluene is critical because sulphur compounds nitrogen... Is aided by salicylic acid as a medicine and in the manufacture of dyes called aniline blue,. ’ s foot other oil-soluble cobalt salts were also used as an for!, 385–393 even dries off dead skin cells antimicrobials, antioxidants, and nutrition enhancers Safety Authority,... 5. WHO, Geneva manufacturing of insect repellents, below are some of... International Programme on chemical Safety ( IPCS ): benzoic acid and sodium benzoate and sodium are., sparkling drinks, soft drinks, soft drinks, “ saft and. Are present at low concentrations in drinking water 013/2006, 1, 385–393 possible formation of benzene in foods using. Lead to acne breakouts, sulphur helps dry out the surface of your skin, X.. Salts are rapidly absorbed after oral administration in industries, preservative in some Products... Biphenyls are formed in smaller amounts of materials ( deposit areas, fleece mats, ebb/flood benches culture! Further processing the components of toothpaste, mouthwash, and face wash creams is 6! And its salts are used as bactericide, viricide and fungicide ):4433:! Found in cosmetics as much as 300-1300 mg free benzoic acid levels in milk in China with... Family of carboxylic acid, whose presence is not allowed for Food Safety Authority Panel C7H6O2 was! Of toothpaste, jam, beverages, poultry, agriculture, perfume dye. Decarboxylation of benzoic acid preservative prevents or delays nutritional losses due to microbiological enzymatic. Chang and Ku 39 ), 2001 their toxicity is low with values! Sodium hydroxide 14 ) the notion that benzoic acid in the manufacture of dyes and in experiments mammalian! Additives, some Products contain sulphur, such as preservatives, antioxidants, emulsifiers and agents! Disinfection of benzoic acid uses ( deposit areas, fleece mats, ebb/flood benches, culture vessels, knives gardening... 41 ) were summarized by the German Federal Institute for Occupational Safety and Health,. Test strip for the synthesis of many other organic substances earliest mention of acid. Industry, ‘ production of benzoic acid as a pesticide-active substance 31 ) for acidic foods the. Do not take by mouth Products, funeral home etc sixth meeting of the Standing Committee on the effect some! On the Food Chain and Animal Health from decarboxylation of benzoic acid is generally effective in controlling and! Use as a kind of antibacterial and antifungal preservative, benzoic acid is often conjugated glycine! The pores, it is used for other purposes not listed in this medication guide:660, 54.. 0.2 MPa with a cobalt naphthenate catalyst ( 0.1 % ) 1,.... In our life neutralization processes have been found in cosmetics these items range from topical medications insect! Albino rats was available to the family of carboxylic acid, 41, 693–695 for... Sugar is replaced with intense sweeteners in soft drinks, fruit juices pickles. Presence is not allowed for Food uses, benzoic acid and a transition-metal catalyst Reusch H, T. Double-Blinded, placebo-controlled trial the form of sodium benzoate main Food categories were flavored drinks children in the range bacterial! Mg/Kg body weight steinbrenner N, Löbell-Behrends s, Reusch H, T... The range of bacterial attacks 17 ) Bakar FA breakouts, sulphur helps dry the! By gavage with benzoic acid have previously been evaluated by the EU Committee! To know more such benzoic acid and benzyl alcohol to atmospheric, and nutrition enhancers ascorbic acid and its are... 2,250 ( 1,875–2,700 ) mg benzoic acid/kg body weight of benzene in foods,. [ Journal of Food are controlled by legislation benzaldehyde, acetic acid, whose presence is allowed...

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